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    <ns1:expectedDelivery xml:lang="en">C (3-6 months)</ns1:expectedDelivery>
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    <dcterms:references rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/25646292"/>
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    <ns1:strainDevelopment xml:lang="ja">開発年：2003年 開発者：長田重一先生・川根公樹先生ら、 機関名：大阪大学大学院生命機能研究科 129Sv の ES 細胞を用いて作成した CAD 遺伝子欠損マウス C57BL/6に対して6回の戻し交配を行った。</ns1:strainDevelopment>
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    <ns4:termsAndConditions xml:lang="en">The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. immunol., 4, 138-144 (2003).RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose.&lt;br&gt;The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.</ns4:termsAndConditions>
    <dcterms:identifier>RBRC01723</dcterms:identifier>
    <ns6:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_3"/>
    <ns1:strainDevelopment xml:lang="en">Developed by Drs. Kohki Kawane and Shigekazu Nagata at Osaka University in 2003.  A neomycin cassette replaced exons 1-6 and part of 7 of Dffb gene.  The mutant mice were backcrossed to C57BL/6.</ns1:strainDevelopment>
    <ns6:brs_depositor xml:lang="ja">長田　重一</ns6:brs_depositor>
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    <ns1:colonyMaintenance xml:lang="en">Backcross to C57BL/6 (Heterozygote x C57BL/6NCrlCrlj) Homozygous mutant mice show no gross developmental abnormalities and are fertile with normal fecundity.</ns1:colonyMaintenance>
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    <rdfs:label>B6;129-Dffb&lt;tm1Osa&gt;/OsaRbrc</rdfs:label>
    <rdfs:label xml:lang="en">B6;129-Dffb&lt;tm1Osa&gt;/OsaRbrc</rdfs:label>
    <skos:altLabel xml:lang="en">CAD KO; CAD Knockout mouse</skos:altLabel>
    <skos:altLabel xml:lang="ja">CAD KO; CAD Knockout mouse</skos:altLabel>
    <ns6:brs_depositorOrganization xml:lang="en">Kyoto Univ.</ns6:brs_depositorOrganization>
    <dc:description xml:lang="en">B6;129-Dffb&lt;tm1Osa&gt;.  CAD, Caspase-activated DNase is an endonuclease that is activated in apoptotic cells.  CAD deficient thymocytes did not undergo apoptotic DNA fragmentation, but their DNA was digested by thymic macrophages that effectively phagocytosed the apoptotic thymocytes.  This strain is useful for elucidation of the function of CAD gene.</dc:description>
    <rdfs:seeAlso rdf:resource="http://www2.brc.riken.jp/lab/animal/detail.php?brc_no=RBRC01723"/>
    <ns1:expectedDelivery xml:lang="ja">C（3〜6か月）</ns1:expectedDelivery>
    <ns6:brs_depositor xml:lang="en">Shigekazu NAGATA</ns6:brs_depositor>
    <ns4:resourceTypeLink rdf:resource="http://metadb.riken.jp/terms/xsearch#resource_type_targeting"/>
    <ns1:colonyMaintenance xml:lang="en">Backcross to C57BL/6 (Heterozygote x C57BL/6NCrlCrlj)  Homozygous mutant mice show no gross developmental abnormalities and are fertile with normal fecundity.</ns1:colonyMaintenance>
    <ns4:termsAndConditions xml:lang="ja">条件を付加する。利用者は事前に寄託者の提供承諾書を得る。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。Nat. immunol., 4, 138-144 (2003).&lt;br&gt;公表を前提とした学術研究に限る。&lt;br&gt;利用者が本件リソースを使用して得られた研究成果に基づき特許等などの申請及び事業を行う場合は寄託者と別途協議を行う。</ns4:termsAndConditions>
    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Approval form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;&lt;A HREF="http://biochemi.ifrec.osaka-u.ac.jp/english/" target="_blank"&gt;Lab HP&lt;/A&gt;</ns4:addinfo>
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    <ns1:publications rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/25646292"/>
    <ns4:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr01723'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns4:addinfo>
    <ns6:brs_hasAllele rdf:resource="http://metadb.riken.jp/db/mgi_rdf/MGI:2449797"/>
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    <ns1:colonyMaintenance xml:lang="ja">注意点など特になし</ns1:colonyMaintenance>
    <ns1:donorDNA>herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Dffb (CAD) genomic DNA</ns1:donorDNA>
    <dc:description xml:lang="ja">CAD 遺伝子 (Gene ID = 13368) のエクソン1〜7をネオマイシン耐性遺伝子に置換したマウス</dc:description>
    <ns6:brs_depositorOrganization xml:lang="ja">国立大学法人京都大学</ns6:brs_depositorOrganization>
    <ns6:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_2"/>
    <ns1:strainDevelopment xml:lang="ja">開発年：2003年開発者：長田重一先生・川根公樹先生ら、機関名：大阪大学大学院生命機能研究科129Sv の ES 細胞を用いて作成した CAD 遺伝子欠損マウスC57BL/6に対して6回の戻し交配を行った。</ns1:strainDevelopment>
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    >true</ns1:isRecombinant>
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/RecoveryTestResult_582">
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